Hyphenated Techniques, an Important Tool for Force Degradation Study
نویسندگان
چکیده
منابع مشابه
Four new degradation products of doxorubicin: An application of forced degradation study and hyphenated chromatographic techniques☆
Forced degradation study on doxorubicin (DOX) was carried out under hydrolytic condition in acidic, alkaline and neutral media at varied temperatures, as well as under peroxide, thermal and photolytic conditions in accordance with International Conference on Harmonization (ICH) guidelines Q1(R2). It was found extremely unstable to alkaline hydrolysis even at room temperature, unstable to acid h...
متن کاملHyphenated Techniques in Gas Chromatography
Hyphenated gas chromatography (GC) (Chaturvedi & Nanda, 2010; Coleman III & Gordon, 2006) mainly refers to the coupling of the high-performance separation technique of gas chromatography with 1) information-rich and sophisticated GC detectors which otherwise can be mostly operated as a stand-alone instrument for chemical analysis, and 2) automated online sample preparation systems. The term “hy...
متن کاملIsolation, Identification, and Characterization of One Degradation Product in Ambroxol by HPLC-Hyphenated Techniques
This study details the isolation, identification, and characterization of ambroxol's unknown impurity. One unknown impurity of ambroxol was formed in the formulated drug under stress conditions [40°C /75% relative humidity (RH) for 6 months] with the relative retention time (RRT) 0.68 in RP-HPLC. The impurity was enriched by exposing it to heat and it was isolated by using preparative HPLC. The...
متن کاملHyphenated Techniques in Environmental Speciation Analysis
The recognition of the fact that the chemical, biological and toxicological properties of an element are critically dependent on the form in which the element occurs in the sample has spurred a rapid development of an area of analytical chemistry referred to as speciation analysis [1]. A fundamental tool used for speciation studies is the combination of a chromatographic separation technique, t...
متن کاملHyphenated techniques for the analysis of heparin and heparan sulfate.
The elucidation of the structure of glycosaminoglycan has proven to be challenging for analytical chemists. Molecules of glycosaminoglycan have a high negative charge and are polydisperse and microheterogeneous, thus requiring the application of multiple analytical techniques and methods. Heparin and heparan sulfate are the most structurally complex of the glycosaminoglycans and are widely dist...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Acta Scientific Pharmaceutical Sciences
سال: 2020
ISSN: 2581-5423
DOI: 10.31080/asps.2020.04.0581